Electric Literature of 762240-92-6,Some common heterocyclic compound, 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, molecular formula is C6H8ClF3N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Take 2.16g of Compound 2 was added to the reaction flask, dissolved with 30ml of ethyl acetate was added CDI1.94g, stirred at room temperature 30min, 3- (trifluoromethyl) -5,6,7,8-tetrahydro- [1, 2,4] triazolo [4,3-a] pyrazine hydrochloride 2.29g and 1.01 g of triethylamine, kept at room temperature and stirred overnight, respectively 1mol / ml hydrochloric acid, washed with 10ml, 1mol / l sodium hydroxide solution 10g washed, 10ml was washed with saturated brine, the organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give a solid 3.34g, yield 85.3%.
The synthetic route of 762240-92-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hefei Hua Fang Pharmaceutical Co., Ltd.; Gao, Yonghao; He, Yong; Peng, Fuyun; Feng, Baolong; Wu, Zhonghao; (6 pag.)CN105330664; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem