41270-66-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41270-66-0 name is 5-Chloro-2,3-diphenylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
6 g of the compound of the formula (1), 7 g of isopropylamine and 5 mL of dimethyl sulfoxide were placed in a sealed pressure-resistant reaction vessel, and the mixture was heated to 90 C for 48 hours, and the reaction was completed. The reaction solution was cooled to 25 C, then 18 mL of ethanol was added, and the solution was dissolved at 80 C, then 24 mL of water was added dropwise over 1 h, a large amount of solid was precipitated, and the temperature was lowered to 25 C, stirred for 0.5 hour, and suction-filtered to obtain a solid.Drying at 80 C for 24 h under vacuum gave 6 g of the compound of formula (2) as a pale yellow solid.The yield was 92.3%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-2,3-diphenylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; Dongguan Dongyangguang Pharmaceutical Research And Development Co., Ltd.; Liu Yongjun; Wang Zhongqing; Liao Shouzhu; Luo Zhonghua; (5 pag.)CN109422698; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem