Synthetic Route of 22047-25-2, The chemical industry reduces the impact on the environment during synthesis 22047-25-2, name is Acetylpyrazine, I believe this compound will play a more active role in future production and life.
A solution of 5.4 g (40 mmol) 1-Pyrazin-2yl-ethanone in 21 ml HBr (33%) and 7 ml methanol was treated with 2.05 ml (40 mmol) bromine and heated to 60 C. for 7 h.The precipitate was filtered off, washed with ethyl acetate/diethyl ether 1/1 and dried to obtain 8.3 g (55%) of the title compound as grey solid. 1-H-NMR (400 MHz, DMSO-d6) delta=8.78 (d, J=2 Hz, 1H, H-5), 8.66 ((d, J=2 Hz, 1H, H-6), 5.01 (s, 2H, CH2), 2.75 (s, 3H, CH3). MS (m/e): 215.0 (M+H, 100%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Acetylpyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Mattei, Patrizio; Neidhart, Werner; Nettekoven, Matthias Heinrich; Pflieger, Philippe; Taylor, Sven; US2003/225141; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem