Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41110-29-6, name is Methyl 3-methylpyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H8N2O2
In a 1 -L flask, the methyl 3-methylpyrazine-2- carboxylate (265A, 16.08 g, 106 mmol) was suspended in CHCl3 (300 mL). 3- Chlorobenzoperoxoic acid (Aldrich, 24.62 g, 143 mmol) was added. The reaction mixture was heated to 70 C for 16 h. The reaction mixture was quenched with saturated NaHCO3 (200 mL). The layers were separated, and the aqueous layer was further extracted with DCM (2 x 100 mL). The combined organic layers were dried over MgSO4, and the filtrate was concentrated to afford crude 3-(methoxycarbonyl)-2-methylpyrazine 1 -oxide (17.77 g). MS m/z=169 [M+H]+. In a 1 -L flask, the crude 3-(methoxycarbonyl)-2-methylpyrazine 1 -oxide (17.77 g, 106 mmol) was dissolved in DMF (300 mL). Neat phosphoryl trichloride (29.6 mL, 317 mmol) was added. The reaction mixture was heated to 100 C. After 1 h, the reaction mixture was concentrated to remove most of the DMF. The flask was cooled in an ice water bath, and 1 M aqueous Na2CO3 (300 mL) was added slowly, followed by 80% EtOAc-hexane (400 mL). The mixture was filtered through Celite filter aid. The resulting filtrate was partitioned and the aqueous phase was extracted further with 80% EtOAc-hexane (2 x 250 mL). The combined organic layers were dried over MgSO4 and concentrated. The material was purified through silica gel using 11 % EtOAc-hexane to afford methyl 5-chloro-3-methylpyrazine-2-carboxylate (265B, 4.29 g, 23 mmol, 22%). MS m/z=187 [M+H]+.
According to the analysis of related databases, 41110-29-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; AMEGADZIE, Albert; BOURBEAU, Matthew P.; BROWN, James A.; CHEN, Jian J.; CHENG, Yuan; FROHN, Michael J.; GUZMAN-PEREZ, Angel; HARRINGTON, Paul E.; LIU, Longbin; LIU, Qingyian; LOW, Jonathan D.; MA, Vu Van; MANNING, James; MINATTI, Ana Elena; NGUYEN, Thomas T.; NISHMURA, Nobuko; NORMAN, Mark H.; PETTUS, Liping H.; PICKRELL, Alexander J.; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert M.; SIEGMUND, Aaron C.; STEC, Markian M.; WHITE, Ryan; XUE, Qiufen; (759 pag.)WO2016/22724; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem