Related Products of 138588-41-7, A common heterocyclic compound, 138588-41-7, name is Pyrazine-2-carboximidamide hydrochloride, molecular formula is C5H7ClN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1,8-diazabicyclo[5.4.0]undec-7-ene (DBU; 14.4 g, 0.0944 mol) is added to a mixture of 2-(2,4,6-triflorophenyl)malonic acid diethyl ester (14.3 g, 0.0472 mol) and pyrazine-2-carboxamidine hydrochloride (9.00 g, 0.0566 mol) in 1-methyl-2-pyrrolidinone (NMP; 50 mL) solvent. The resulting mixture is heated to 95 C. while stirring for 7 hours. The mixture is cooled to about 50 C. and then HCl solution (37%, 5.6 mL) is added dropwise, keeping the temperature below 50 C. The mixture is then allowed to cool to about 20 C. Water (50 mL) is added dropwise over 20 minutes, causing the product to precipitate as a solid from the mixture (20-25 C.). The solid is collected by filtration, and the product cake is washed with water (300 mL). The solid is allowed to dry at 23 C. under atmospheric pressure for 24 hours, giving a yellow solid (11.5 g, 97% HPLC area, 76% yield. 1H NMR (DMSO-d6): d 12.45 (bs, 2H), 9.41 (s,1H), 8.91 (s,1H), 8.46 (m, 1 H), 7.23 (m, 2H).
The synthetic route of 138588-41-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wyeth; US2006/281760; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem