Reference of 24241-18-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24241-18-7, name is 2-Amino-3,5-dibromopyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Step A: 5-Bromo-3-phenylpyrazin-2-amineTo a deoxygenated solution of 3,5-dibromopyrazin-2-amine (5.00 g, 19.8 mmol) in 1,4- dioxane (100 mL) was added potassium carbonate (8.20 g, 59.3 mmol), phenylboronic acid (2.17 g, 17.8 mmol) and Pd(dppf)Ci2 (1.45 g, 1.98 mmol). The resulting mixture was heated at 90 C for 4 h, then cooled and partitioned between water (50 mL) and EtOAc (50 mL x 2). The combined organic layers were dried over a2S04 and concentrated, and the residue was purified by column chromatography on silica gel (PE/EtOAc = 15/1, 10/1, 5/1) to give the title compound. MS: m/z = 249.9 (M + 1).
The synthetic route of 2-Amino-3,5-dibromopyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO., LTD.; MITCHELL, Helen; FRALEY, Mark, E.; COOKE, Andrew, J.; CHEN, Yi-Heng; STUMP, Craig, A.; ZHANG, Xu-Fang; MCCOMAS, Casey, C.; SCHIRRIPA, Kathy; MCWHERTER, Melody; MERCER, Swati, P.; BABAOGLU, Kerim; MENG, Dongfang; WU, Jane; LIU, Ping; WOOD, Harold, B.; BAO, Jianming; LI, Chun Sing; MAO, Qinghua; QI, Zhiqi; (263 pag.)WO2015/148344; (2015); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem