Reference of 356783-16-9, The chemical industry reduces the impact on the environment during synthesis 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, I believe this compound will play a more active role in future production and life.
3.48 g of 3,6-dichloro-2-cyanopyrazine (3) was mixed with 10 mL of dry dimethylsulfoxide,Dry potassium fluoride 5.23g and tetrabutylammonium bromide 2.15g mixed evenly, sealed heating,Control reaction temperature 55 , stirring reaction 3h, the reaction is completed and rushed into 10mL cold water,Extracted three times with ethyl acetate (20 mL * 3)The organic phases were combined, washed twice with saturated brine,The organic phase was dried over anhydrous sodium sulfate and filtered,To a solution of 1.49 g of pale yellow solid 3, 6-difluoro-2-cyanopyrazine (4)Yield 52.80%, m.p. 56-57 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dichloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhengzhou University; Li Mengyang; (6 pag.)CN107226794; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem