These common heterocyclic compound, 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 24241-18-7
2-chloroacetaldehyde (0.79 g, 4 mmol) was slowly added to a freshly prepared solution of 3,5-dibromopyrazin-2-amine (1) (0.51 g, 2 mmol) in 2-propanol (20 mL). The mixture was stirred at reflux under a nitrogen atmosphere for 24 h. After cooling, CH2Cl2 (25 mL) and Et3N (1 mL) were added to the reaction solution. Thereafter, the solvent was evaporated under reduced pressure, and then the residue was washed with 11 mL mixed solution (water: 2-propanol = 10:1) for 2 times, filtered and dried under vacuum to give 6,8-dibromoimidazo[1,2-a]pyrazine (2) as a brown solid, which was pure enough to be used in the next step without further purification.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24241-18-7.
Reference:
Article; Huang, Boshi; Liang, Xin; Li, Cuicui; Chen, Wenmin; Liu, Tao; Li, Xiao; Sun, Yueyue; Fu, Lu; Liu, Huiqing; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 330 – 337;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem