Electric Literature of 63744-29-6, The chemical industry reduces the impact on the environment during synthesis 63744-29-6, name is 5-Bromo-[1,2,4]triazolo[4,3-a]pyrazine, I believe this compound will play a more active role in future production and life.
Step 1: (3S,4 ?)-tert-butyl 4-(([l,2,4]triazolo[4 -a]pyrazin-5-ylamino)methyl)-3-fluoropiperidine- 1-carboxylate [0185] A mixture of 5-bromo-[l,2,4]triazolo[4,3-a]pyrazine (102 mg, 0.51 mmol), (3S,4R)-tert-butyl 4- (aminomethyl)-3-fluoropiperidine-l-carboxylate (80 mg , 0.34 mmol) and DIPEA (1.2 mL, 1.0 mmol) in ethylene glycol (2 mL) was heated to 110 C in the sealed tube for 7 hr under N2 atmosphere. The mixture was allowed to cool to rt and concentrated. The concentrate was partitioned into DCM and water. The organic phase was washed with water, brine, dried over Na2S04 and concentrated. The concentrate was purified by column chromatography over silica gel (MeOH/DCM=50/l) to afford the title compound as an off-white powder (60 mg, 50%). MS (ESI) calcd for C16H23FN602: 350.2; found: 351.3[M+H]. 1H NMR (400 MHz, CDCI3) delta 8.72 (s, 1H), 7.41 (d, J = 4.8 Hz, 1H), 7.34 (d, J = 4.8 Hz, 1H), 6.55-6.47 (m, 1H), 4.90-4.65 (m, 1H), 4.62-4.35 (m, 1H), 4.33-4.05 (m , 1H), 3.74-3.64 (m, 2H), 2.96-2.62 (m, 2H), 2.24 -2.04 (m, 1H), 1.73-1.58 (m, 1H), 1.46 (s, 9H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-[1,2,4]triazolo[4,3-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon; (239 pag.)WO2016/100349; (2016); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem