23688-89-3, Adding some certain compound to certain chemical reactions, such as: 23688-89-3, name is 6-Chloropyrazine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23688-89-3.
To a 100 ml round bottom flask, 6-chloropyrazine-2-carboxylic acid (Ig, 6.31 mmol) was suspended in dry CH2Cl2 (30ml). Oxalyl chloride (3.78 ml, 7.57 mmol) was added along with a few drop of DMF, the mixture was stirred at room temperature for 12 hrs, N, O- Dimethylhydroxylamine hydrochloride (0.800 g, 8.20 mmol) was added, the resulting mixture was cooled down to 5C, TEA (2.64 ml, 18.92 mmol) was added via a droping funal, the reaction mixture was stirred at room temperature for 30 minutes, filtered and the filter cake was washed with EtOAc, the combinded filtrate was washed with saturated sodium bicarbonate and brine, concentrated to an oil, purified on silica gel with Hexanes/EtOAc solventsto give product (1.06g). MS (ES) MH+: 202 for C7H8ClN3O2
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 23688-89-3.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BARVIAN, Kevin; BASARAB, Gregory, Steven; GOWRAVARAM, Madhusudhan, Reddy; HAUCK, Sheila, Irene; ZHOU, Fei; WO2010/43893; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem