23611-75-8, A common compound: 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Example 66Methy[ 6- ({4-[(3,4-dif[uoropheny[)carbamoy[]-3-methy[- 1 ,2-thiazo[-5-y[lamino)-pyrazine-2-carboxy[ate A mixture of 5-amino-N-(3,4-dif[uoropheny[)-3-methy[-1 ,2-thiazo[e-4-carboxamide [Intermediate 3] (150 mg, 0.56 mmo[, 1.0 eq), methy[ 6-ch[oropyrazine-2- carboxy[ate [CAS RN: 23611-75-8] (120 mg, 0.56 mmo[, 1.0 eq) and cesiumcarbonate (417 mg, 1.28 mmo[, 2.3 eq) in 5.4 mL dioxane/DMF (7/1) was p[aced ina microwave via[ and f[ushed with argon. Then, pa[[adium(II) acetate (13 mg,0.06 mmo[, 0.1 eq) and Xantphos (32 mg, 0.06 mmo[, 0.1 eq) were added. The via[was capped and the reaction mixture was stirred at an environmenta[ temperatureof 110 C overnight. On coo[ing, the vo[ati[e components were removed in vacuo.The crude materia[ was disso[ved in a sma[[ amount DM50 and fi[tered. Purificationwas conducted via preparative HPLC (method A) to give 10 mg (4 % yie[d of theory) of the tit[e compound.UPLC-MS (Method 1): R = 1.20 mm; MS (ESIneg) m/z = 404 [M-H].1H-NMR (400 MHz, DMSO-d6): oe [ppm] = 3.98 (s, 3H), 7.38-7.53 (m, 2H), 7.95 (m,1H), 8.73 (s, 1H), 8.84 (s, 1H), 10.48 (s, 1H), 11.22 (s br, 1H), 1xCH3 not assigned.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 6-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; PRECHTL, Stefan; SIEMEISTER, Gerhard; WENGNER, Antje Margret; ACKERSTAFF, Jens; NOWAK-REPPEL, Katrin; BADER, Benjamin; LIENAU, Philip; STOeCKIGT, Detlef; WO2014/118186; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem