Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., 36070-80-1
[0109] At 0C, a solution of oxalyl chloride (2.52 g, 0.02 mol) in dichloromethane (10 mL) is dripped dropwise into asuspension of 5-chloropyrazine-2-carboxylic acid (1.56 g, 0.01 mol) and N,N-dimethyl formamide (1 drop) in dichloromethane(100 mL). After being stirred overnight at room temperature, the reaction mixture is evaporated under vacuum,and the trace amount of oxalyl chloride is removed twice by additional dichloromethane (100 mL) azeotropic mixture togive compound (4-2) (1.77 g, 100%).
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Reference:
Patent; Hangzhou Bensheng Pharmaceutical Co., Ltd.; XU, Rongzhen; XIE, Fuwen; LAI, Hongxi; RONG, Frank; EP2615092; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem