55557-52-3, The chemical industry reduces the impact on the environment during synthesis 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, I believe this compound will play a more active role in future production and life.
To a solution of rert-hutyl 4-(ir,4-4-hydroxycyclohexyioxy)piperidine-i -carboxylate (W0201 1127051) (4 g, 13.36 mmol) in THF (10 mL) was added 1 M potassium tert-butoxide solution in THF (16.03 mL, 16.03 mmol) at 0 E/ under nitroger. After stirring for 10 mm, asolution of 3-chioropyrazine-2–earbonitrile (2.051 g, 14.70 mmoi) in THF (6 mL) was added. The reaction mixture was slowly warmed to room temperatuw and stirred for I Ii. The mixture was quenched with water and 1 N HC1 (aq) and extracted with EtOAc. The organic layer was washed with brine, dried with anhydrousMgSO,, fihered, and concentrated under reducedpressure. The residue was purified by silica gel column chromatography to afford the titlecompound (4.80 g, 11.9 mmoi, 89,3%), Exact mass calculated for C21H30N404: 402.2, fOundLCMS m/z =403.2 [M¡ÀHf; ?H NMR (CDCI1, 400 MHz) S ppm 1.46 (s, 9H), 1.46-1.58 (m,4Fl). 1.65-1.72 (m, 2H), 1.75-1.82 (in, 21-1). 1.96-2.05 (in. 2H). 2.10-2.18 (m, 2H), 3.05-3.12(m, ZR), 3.52-3.58 (m, 21-i). 3.73-3.82 (m. 21-1), 5.18-5.25 (m, Hi), 8.22 (d, J= 2.5 Hz, 11-i).8.29 (d, .J= 2,5 Hz. 11-I).
The chemical industry reduces the impact on the environment during synthesis 3-Chloropyrazine-2-carbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; THE UNIVERSITY OF COPENHAGEN; JONES, Robert M.; SCHWARTZ, Thue Walter; KRISTENSEN, Line Vildbrad; MADSEN, Torben Andreas Nygaard; WO2014/74700; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem