A common compound: 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 113305-94-5
A solution of thiophosgene (1.86 g, 15 mmol) in THF (4 mL) is added dropwise to a solution of 5-aminopyrazine-2-carbonitrile (1.20 g, 10 mmol) and pyridine (2 mL) in CH2Cl2 (200 mL) and THF (25 mL) at room temperature. The reaction mixture is stirred at room temperature for 3 h. The mixture is concentrated and the crude product is diluted with ethyl acetate, filtered and concentrated to give the title compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 113305-94-5, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Farouz, Francine S.; Holcomb, Ryan Coatsworth; Kasar, Ramesh; Myers, Steven Scott; US2011/144126; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem