Some common heterocyclic compound, 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, molecular formula is C6H7F3N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 486460-21-3
Step: 20aSynthesis of 7-(4-Nitro-phenyl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[l,2,4]triazolo[4,3- ajpyrazine.Procedure:K2C03 (4.4g, 0.053mol), followed by l-Fluoro-4-nitro-benzene (1.5g, 0.0177mol) was added to a solution of 3-Trifluoromethyl-5,6,7,8-tetrahydro-[l,2,4]triazolo[4,3- a]pyrazine (3.2g, 0.0230mol) in DMF (15ml), and the flask was stirred for 6hrs at 80C. The reaction was monitored by the TLC (20% ethylacetate in hexane). From the resulting reaction mixture DMF was distilled, the residue was purified by column chromatography (using silica gel of mesh size of 60-120, 20% ethylacetate in hexane as eluant) to afford 1.2g (36.36% yield) of 7-(4-Nitro-phenyl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[l ,2,4]triazolo[4,3- ajpyrazine.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 486460-21-3, its application will become more common.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara; WO2012/59932; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem