In an article, author is Shamraiz, Umair, once mentioned the application of 2847-30-5, Formula: C6H8N2O, Name is 2-Methoxy-3-methylpyrazine, molecular formula is C6H8N2O, molecular weight is 124.1405, MDL number is MFCD00006127, category is Pyrazines. Now introduce a scientific discovery about this category.
Synthesis of new boswellic acid derivatives as potential antiproliferative agents
In the current investigation, a series of heterocyclic derivatives of boswellic acids were prepared along with new monomers of 3-O-acetyl-11-keto-beta-boswellic acid (AKBA,1) 11-keto-beta-boswellic acid (KBA,2) and several new bis-AKBA and KBA homodimers and AKBA-KBA heterodimers. The effects of these compounds on the proliferation of different human cancer cell lines, viz., FaDu (pharynx carcinoma), A2780 (ovarian carcinoma), HT29 (colon adenocarcinoma), and A375 (malignant melanoma), have been evaluated. Thus, KBA homodimer21effectively inhibited the growth of FaDu, A2780, HT29, and A375 cells with EC(50)values below 9 mu M. In addition, compounds7,8,11,12,15,16,and17also exhibited cytotoxic effects for A2780, HT29, and A375 cancer cells. In particular, the pyrazine analog8was highly cytotoxic for A375 cancer cells with an EC(50)value of 2.1 mu M.
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