Adding a certain compound to certain chemical reactions, such as: 5049-61-6, name is Pyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5049-61-6, Product Details of 5049-61-6
At room temperature,2-aminopyrazine (8.00 g, 84.12 mmol) was dissolved in dimethylsulfoxide (160 mL)Add water (4 mL),Ice bath,N-bromosuccinimide (31.50 g, 177.00 mmol) was added portionwise to the reaction solution over 30 min,Feeding is completed,Stirred at room temperature overnight,Add water (500mL) quenching,Ethyl acetate (500 mL x 3)Dried over anhydrous Na2SO4,The solvent was removed and the residue was subjected to column chromatography (eluent: PE / EtOAc (v / v) = 6/1) to give 16.40 g of light yellow Color solid, yield: 76.6%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Liu, Bing; Huang, Jiuzhong; Zhang, Yingjun; Xue, Yaping; Xing, Wei; Xu, Juan; Wu, Zuping; Yu, Tianxi; (106 pag.)CN106432246; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem