Adding a certain compound to certain chemical reactions, such as: 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 313339-92-3, HPLC of Formula: C5HCl2N3
A solution of compound C1-4 (1.90 g, 4.67 mmol) and TFA (6.00 mL) in DCM (20 mL) was stirred for 1H at RT. The resulting mixture was concentrated under reduced pressure. 3,5-dichloropyrazine-2-carbonitrile (818 mg, 4.70 mmol) , DMSO (8 mL) and DIPEA (6.56 g, 50.76 mmol) was added and stirred for 1H at 70 . The reaction mixture was diluted with water (50 mL) and extracted with EA (2 ¡Á 50 mL) . The combined organic layers were dried over anhydrous Na 2SO 4, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (eluting with EA : Hex = 1 : 2, v/v) to give compound 50-1 (1.81 g) . MS: 444 [M+1] +.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dichloropyrazine-2-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; JACOBIO PHARMACEUTICALS CO., LTD.; HAN, Huifeng; GAO, Panliang; MA, Cunbo; KANG, Di; (214 pag.)WO2020/63760; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem