Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19745-07-4, name is 2,5-Dichloropyrazine, This compound has unique chemical properties. The synthetic route is as follows., 19745-07-4
To a solution of l-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(piperidin-4- yl)imidazolidin-2-one 2,2,2-trifluoroacetate (Intermediate 10; 0.2 g, 0.410 mmol) in DMF (2 mL) was added N-ethyl-N-isopropylpropan-2-amine (0.300 mL, 1.641 mmol) and 2,5- dichloropyrazine (0.0917 g, 0.615 mmol) and the reaction was heated to 100 ¡ãC for 8 hours. The reaction was diluted with EtOAc (100 mL), washed with water (50 mL) and brine (50 mL), dried over MgS04, filtered and concentrated in vacuo. The crude material was chromatographed eluting with 7:3 EtOAc/Hexane to yield a solid, which was further purified by reverse phase preparative HPLC to give l-(l-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2,5- difluoro-4-(methylsulfonyl)benzyl)imidazolidin-2-one (0.0071 g, 0.0146 mmol, 3.6percent yield). Mass spectrum 485.7, 487.7 (M+H).
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Reference:
Patent; ARRAY BIOPHARMA INC.; FELL, Jay Bradford; FISCHER, John P.; HINKLIN, Ronald J.; WO2013/74641; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem