6863-74-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6863-74-7 name is 6-Chloropyrazine-2-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 1F (60 mg), 6-cyano-2-chloropyrazine (26 mg), KF (1 mg) and TEA (0.07 mL) were combined in a microwave tube and dissolved in ACN (2 mL). The reaction mixture was stirred in the micro wave oven at 130 C. for 1 h. The reaction mixture was filtrated and purified by preparative HPLC to yield an off-white solid (9 mg; 12%). MS: m/z=462.3 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Chloropyrazine-2-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Banner, David; Grether, Uwe; Haap, Wolfgang; Kuehne, Holger; Mauser, Harald; Plancher, Jean-Marc; US2012/115843; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem