Synthetic Route of 32111-21-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32111-21-0, name is 2-Iodopyrazine, This compound has unique chemical properties. The synthetic route is as follows.
Pd2(dba)3 -CHCl3 (5 mg, 0.5 mol %), 2′-(dicyclohexylphosphino)biphenyl-2-amine (8 mg, 2 mol %) and sodium tert-butoxide (13 mg, 0.14 mmol) were weighed in air and transferred into flask, followed by dioxane (750 muL), 1 ‘-(piperidin-4- yl)spiro[benzo[d][l,3]oxazine-4,4’-piperidin]-2(lH)-one bis-hydrochloride (compound no. 49) (37 mg, 0.10 mmol) and iodopyrazine (viia). (20.6 mg, 0.10 mmol). The flask was flushed with nitrogen and stirred at 800C for 16 hours. The reaction mixture was diluted with methanol (500 muL), filtered (Whatman 0.45 mum PTFE) and subjected to reverse-phase
The chemical industry reduces the impact on the environment during synthesis 2-Iodopyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/21375; (2008); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem