5049-61-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5049-61-6 as follows.
Step 3b: NBS Bromide Formation (Aryl) (Int-118) 2-Aminopyrazine (4 g, 42 mmol) was dissolved in water (2 mL) and DMSO (70 mL), and NBS (7.5 g, 42 mmol) was added over 1 hour at 0 C. The reaction was warmed to room temperature and stirred overnight. The mixture was poured onto ice and extracted 4 times with EtOAc. The combined organic layers were washed with 5% Na2CO3, water, and brine, dried over MgSO4, filtered, and concentrated. The residue was purified on silica gel to give the desired product.
According to the analysis of related databases, Pyrazin-2-amine, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Amira Pharmaceuticals, Inc.; US2007/105866; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem