Reference of 98-97-5,Some common heterocyclic compound, 98-97-5, name is Pyrazine-2-carboxylic acid, molecular formula is C5H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Diphenyl phosphorylazide (8.6 g) was added dropwise to a solution of pyrazine-2- carboxylic acid (3 g) in THF (30 ml) and TEA (9 ml) and the resulting reaction mixture was stirred at RT for 2 hours. On completion, THF was removed under reduced pressure to give a residue, which was further purified by column chromatography (SiO2, gradient 10-40 % EtOAc/n-hexane) yielding the desired product (2.5g, 70%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2-carboxylic acid, its application will become more common.
Reference:
Patent; SENTINEL ONCOLOGY LIMITED; WO2007/144579; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem