Related Products of 6705-33-5,Some common heterocyclic compound, 6705-33-5, name is Pyrazin-2-ylmethanol, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 5 mL of diethyl ether was added 2-hydroxymethylpyrazine (100 mg, 0.9 mmol), stirred at room temperature, and 60% sodium hydride(80 mg, 2 mmol). After stirring was continued for 10 minutes, trichloroacetonitrile (202 mg, 1.4 mmol) was added,The reaction was complete after 2 hours by TLC. The residue was purified by column chromatography on a rotary evaporator (petroleum ether: ethyl acetate = 30: 1) to give 160 mg of product in 70% yield.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazin-2-ylmethanol, its application will become more common.
Reference:
Patent; Fudan University; Shao Liming; Xu Yulong; Chen Yiyi; Li Wei; Xie Qiong; (25 pag.)CN107151254; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem