In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33332-25-1 as follows. Formula: C6H5ClN2O2
Synthesis of 2,3<5,6-Tetrahydro-ri,2'1bipyrazinyl-4,5'-dicarboxylic acid 4-tert-butyl ester (Intermediate 1-3.1)Step 1: Synthesis of 2,3,5,6-Tetrahydro-ri,2'lbipyrazinyl-4,5'-dicarboxylic acid 4-tert- butyl ester 5'-methyl ester (R8)A 250ml RB flask is charged with R7 (2.8 g, 16.11 mmol) in 60mL of NMP. R6 (3.0 g, 16.11 mmol) is added followed by triethylamine (2.7 ml, 19.33 mmol). The reaction is warmed to 60 C under nitrogen and stirred overnight. After 18 h, the reaction is cooled to room temperature, poured into ice water and the resulting solid R8 is isolated by filtration and used without further purification. (5.0 g)
According to the analysis of related databases, 33332-25-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; DINES, Jonathon Alan; HUBER, John, D.; LIU, Weimin; LO, Ho Yin; LOKE, Pui Leng; MORWICK, Tina Marie; NEMOTO, Peter Allen; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee, M.; WO2012/27322; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem