Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4858-85-9, name is 2,3-Dichloropyrazine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2,3-Dichloropyrazine
A thick-walled reaction vessel (250 mL) charged with 2, 3-dichloropyrazine (14.9 g, 95 mmol) and 28-30% ammonium hydroxide (75 mL) was sealed in vacuo, submitted to a freeze-pump- thaw cycle and then heated with stirring to 135 C for 15 h. Upon cooling of the reaction mixture, needles were observed to form from the reaction mixture. The supernatant was decanted off and the residual solid was solubilized in hot methanol. The methanol solution was concentrated in vacuo and the resultant crude material (10. 8 g) was recrystallized from methanol (150 mL) to yield 8.26 g of the title compound (67% yield). mp 167-168 C ; Rf 0.5 (EtOAc-hexanes, 1 : 1, v/v, +0.5% v/v iPrNH2) ;’H NMR (DMSO-d6) 8 8.9 (s, 1H), 8. 7 (s, 1H), 5.0 (br s, 2H)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4858-85-9.
Reference:
Patent; CARDIOME PHARMA CORPORATION; WO2005/34837; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem