Synthetic Route of 22047-25-2, A common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, molecular formula is C6H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A 2-neck round bottom flask attached with calcium chloride guard tube was charged with MeOH (30mL). Then, 2-acetylpyrazine (1.47g, 2mmol) followed by KOH pellets (0.675g, 2mmol) were added and initiated magnetic stirring. To this mixture, distilled water (2mL) was added and continued stirring for 10min. Now, the resulting solution was added the respective n,n?,n?-trimethoxyphenyl benzaldehydes (1.0g, 1mmol) under stirring at room temperature slowly and then 6mL of ammonia solution was added. The reaction mixture was stirred further for 4h. The reaction was monitored by TLC. On completion of reaction by TLC, the reaction mass was filtered and washed with methanol (3¡Á10 mL) and then diethyl ether (3¡Á10 mL) to obtain a white precipitate of respective compounds. Each of the above precipitates was recrystallised in a mixture of CHCl3 and MeOH (1:1) at room temperature for 48h. The resulting colourless single crystals of 1-3 were collected by filtration.
The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ramesh; Sharath Kumar; Raghavendra Kumar; Suchetan; Devaraja; Sabine, Foro; Nagaraju; Journal of Molecular Structure; vol. 1200; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem