Application of 160252-31-3, These common heterocyclic compound, 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 1-(5-chloropyrazin-2-yl)ethanone in ethanol (25 mL) was added to a solution of sodium ethoxide in ethanol at 0 C. The reaction mixture turned into a yellowish brown slurry. After it was stirred at 0 C. for 1 h, the reaction was quenched with saturated aqueous NH4Cl. The mixture was extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography (0-30% EtOAc/hexanes) to give the title compound
The synthetic route of 160252-31-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme Corp.; Berger, Richard; Blizzard, Timothy A.; Campbell, Brian T.; Chen, Helen Y.; Debenham, John S.; Dewnani, Sunita V.; Dubois, Byron; Gude, Candido; Guo, Zack Zhiqiang; Harper, Bart; Hu, Zhiyong; Lin, Songnian; Liu, Ping; Wang, Ming; Ujjainwalla, Feroze; Xu, Jiayi; Xu, Libo; Zhang, Rui; (64 pag.)US2018/9796; (2018); A1;,
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