Synthetic Route of 22047-25-2, A common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, molecular formula is C6H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Hydrazinylbenzoisothiazole-1,1-dioxide (138mg; 0.7mmol) and acetylpyrazine (122mg; 1mmol) were mixed in isopropanol (25mL), and acetic acid (1mL) was added. The reaction mixture was then stirred at 75C for 2days. The volatile compounds were then evaporated under reduced pressure, and the residue was suspended in diethyl ether/petroleum ether mixture (1:1, v/v; 30mL). Solid material was filtered, washed with additional diethyl ether/petroleum ether mixture (1:1, v/v; 60mL) and dried at 50C under vacuum. 3-(2-(1-(Pyrazin-2- yl)ethylidene)hydrazinyl)-1,2-benzothiazole 1,1-dioxide (4) was obtained with a yield of 164mg (78%) as a yellowish solid. 1H NMR (DMSO-d6): 2.55 and 2.61 (2x s, 3H); 7.92 (m, 2H); 8.10 (s, 1H); 8.45 and 8.70 (2x m, 1H); 8.75 (m, 2H); 9.30 (s, 1H); 11.70 and 12.37 (2x bs, 1H) ppm. 13C NMR (DMSO-d6): delta 12.8 (13.6); 121.7 (121.6); 124.2; 126.7; 129.6; 133.8 (134.1); 133.9; 142.5; 143.0; 143.6 (143.8); 145.3 (145.0); 149.8 (149.7); 154.7 (159.9) ppm. ESI-MS (m/z): 302 [M+H]+. Elem. Anal. Calcd. for C13H11N5O2S: C, 51.82; H, 3.68; N, 23.24. Found: C, 51.80; H, 3.72; N, 23.26.
The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jakubek, Milan; Kejik, Zden?k; Kaplanek, Robert; Antonyova, Veronika; Hromadka, Robert; ?andrikova, Viera; Sykora, David; Martasek, Pavel; Kral, Vladimir; Bioorganic Chemistry; vol. 88; (2019);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem