Related Products of 912773-21-8, These common heterocyclic compound, 912773-21-8, name is 2-Bromo-5-chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N2 was bubbled through a solution of the product from step 1 (0.37 mmol) in toluene for 30 min. Separately, a flask was charged with 2-bromo-5-chloropyrazine (108 mg, 0.56 mmol), (Ph3P)4Pd (21.5 mg, 0.19 mmol) and copper(I) iodide (7.1 mg, 0.037 mmol), then sealed evacuated and purged with N2 thrice. The toluene solution was inhjected in to the flask and the solution stirred at 100 C for 3 h 15 min. The cooled solution was concentrated in vacuo to ~1/2 volume. FCC (5-40% EtOAc in cyclohexane) gave the title compound as a solid (97 mg). LCMS (Method A) 4.66 min, ES+ 476 [M+1]+.
Statistics shows that 2-Bromo-5-chloropyrazine is playing an increasingly important role. we look forward to future research findings about 912773-21-8.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BRONNER, Sarah M.; CRAWFORD, James J.; CRIDLAND, Andrew; CYR, Patrick; FAUBER, Benjamin; GANCIA, Emanuela; GOBBI, Alberto; HURLEY, Christopher; KILLEN, Jonathan; LEE, Wendy; RENE, Olivier; VAN NIEL, Monique Bodil; WARD, Stuart; WINSHIP, Paul; ZBIEG, Jason; (439 pag.)WO2018/83105; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem