Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H7F3N4
A mixture of (3S,4S)-i -(6-chloro-3-cyanoquinolin-4-yl)-3 -methoxypiperidine-4-carboxylic acid (65 mg, 0.187 mmol), 3-(trifluoromethyl)-5,6,7,8-tetrahydro- [1,2,4jtriazolo[4,3-ajpyrazine (40 mg, 0.206 mmol), HATU (142 mg, 0.375 mmol) and DIPEA (131 1iL, 0.749 mmol) in DMF (3 mL) was stirred at 16 C for 1.5 h. Water (20 mL)was added and the mixture was extracted with EtOAc (3 x 8 mL). The combined organic layers were dried with Na2504, filtered and concentrated. The residue was purified by prepHPLC then dried by lyophilization to 6-chloro-4- [(3S,48)-3 -methoxy-4- { [3 -(trifluoromethyl)5 ,6-dihydro [1 ,2,4jtriazolo [4,3-al pyrazin-7(8H)-ylj carbonyl } piperidin- 1 -ylj quinoline-3- carbonitrile (Human CYP8B 1 150 (nM) 22) and 6-chloro-4- [(3S,4R)-3-methoxy-4- { [3-(trifluoromethyl)-5 ,6-dihydro [1 ,2,4jtriazolo[4,3 -ajpyrazin-7(8B)-ylj carbonyl } piperidin- 1- yljquinoline-3-carbonitrile (Human CYP8B1 1C50 (nM) 441). MS: 556 (M + 1).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 486460-21-3.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CUMMING, Jared, N.; DYKSTRA, Kevin, D.; HRUZA, Alan; LI, Derun; LIU, Hong; TANG, Haiqun; TAOKA, Brandon, M.; VERRAS, Andreas; WALSH, Shawn, P.; WU, Wen-Lian; (170 pag.)WO2018/34918; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem