Synthetic Route of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Sulfuric acid (19 mu, 0.36 mmol) was added to a methanol (1.2 mL, 29 mmol) solution of pyrazine-2,5-dicarboxylic acid (Ark Pharma cat AK-76746, 100 mg, 0.6 mmol). Then the mixture was allowed to stir at 90 C overnight. After cooling to rt, the mixture was diluted with methanol and basified with NaOH aq. Then the mixture was allowed to stir at rt for 5 h to reach -50% conversion to afford the mono-ester. Then the mixture was acidified with HC1 aq, and extracted with DCM/iPrOH x 3. The organic layer was dried and concentrated to afford desired product, which was used in the next step without further purification. LC-MS calculated for C7H7N2O4 (M+H)+: m/z = 183.0; found 183.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2,5-dicarboxylic acid, its application will become more common.
Reference:
Patent; INCYTE CORPORATION; WU, Liangxing; YU, Zhiyong; ZHANG, Fenglei; YAO, Wenqing; (173 pag.)WO2017/106634; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem