In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 762240-92-6 as follows. Product Details of 762240-92-6
The (R) – 3 – (tert-butoxycarbonylamino) – 4 – (2, 4, 5-trifluorophenyl) butanoic acid (26.6g), 2,6-dimethyl pyridine (18g) and 3 – (trifluoromethyl) – 5, 6, 7, 8-tetrahydro-[ 1, 2, 4] triazolo [4,3-a] pyrazine hydrochloride (17.3g) are sequentially added dichloromethane (300 ml) in, cooling to 0-5C, stirring, add TBTU (28.2g), natural recovery to the room temperature, to continue reaction 8-10 hours. After the reaction, the organic phase for sequentially 1NHCl (200 ml), water (200 ml), 5% sodium carbonate aqueous solution (200 ml), saturated aqueous sodium chloride solution (200 ml) washing, dry anhydrous sodium sulfate, filtered, concentrated under reduced pressure, to obtain white foam solid 36g, yield 90%. 1 HNMR (400MHz, CDCl 3) delta 1.39 (s, 9H), 2.59-2.72 (m, 2H), 2.79-2.96 (m, 2H), 3.96-4.38 (m, 5H), 4.95 (s, 1H), 4.98-5.10 (m, 1H), 5.31 (b, 1H), 6.89-6.93 (m, 1H), 6.97-7.06 (m, 1H).
According to the analysis of related databases, 762240-92-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Aobo Pharmtech, Inc., Ltd.; Zhejiang Huahai Pharmaceutical Co., Ltd; Zhu, Wei; Fan, Qianyong; Ruan, Hongliang; (12 pag.)CN102757431; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem