Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4949-13-7, name is 2-Fluoropyrazine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C4H3FN2
To a stirred solution of 2-fluoropyrazine (1 g, 10.20 mniol) in DMO (12 mL) was added 3-brorno-4-fluorophenoi (1.95 g, 10.21 mmoi), and K2C03 (2.82 g, 20.39 mmol), The reactionmixture was stirred at 75C for 15 h. The mixture was filtered, and the filtrate was diluted with brine (50 mL). The filtrate was extracted with EIOAc (2×100 mE), The organic layer was dried over NaO4, filtered and concentrated in vacuo to give the title compound. m/z 270.9(M¡À2+H).
According to the analysis of related databases, 4949-13-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem