63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C4H5ClN4
STEP2 Preparation of N’-(3-chloropyrazin-2-yl)-2,2,2-trifluoroacetohydrazide To a solution of 2-chloro-3-hydrazinylpyrazine (4.50 g, 31.1 mmol) in THF (104 mL) was dropwise added TFAA (5.72 mL, 40.5 mmol) at 0 C. The reaction mixture was stirred at room temperature for 1 hour and MeOH:DCMuenched with water. The mixture was extracted DCM, washed with water, dried over Na2SO4, filtered and concentrated in vacuo to afford N’-(3-chloropyrazin-2-yl)-2,2,2-trifluoroacetohydrazide (2.76 g, 37%) as a yellow solid, which was used for the next reaction without further purification. 1H-NMR (DMSO-d6, 400 MHz): delta 11.6 (1H, s), 9.47 (1H, s), 8.18 (1H, d, J=2.8 Hz), 7.88 (1H, d, J=2.4 Hz).
The synthetic route of 63286-28-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HANDOK INC.; Lee, Jin-Hwa; Kim, Seung-Yong; Kim, Do-Ran; Ahn, Koo-Hyeon; Lee, Gwi-Bin; Kim, Doo-Seop; Hwang, Hyun-Sook; (74 pag.)US2017/204101; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem