Synthetic Route of 56423-63-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56423-63-3 name is 2-Bromopyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Into a 25-mL round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed 2-chloro-5-[[4-methyl-6-(methylarnino)pyrimidin-2-yl]amino]benzarnide (100 mg, 0.34 mmol, 1.00 equiv), Xantphos (8 mg, 0.07 mmol, 0.20 equiv), Pd2(dba)3 (7 mg, 0.03 mmol, 0.10 equiv), Cs2C03 (200 mg, 0.68 mmol, 2.00 equiv), DMSO (5 raL), 2-bromopyrazine (55 mg, 0.35 mmol, 1 .00 equiv). The resulting solution was stirred for 8 h at 80 C in an oil bath . The solids were fi ltered out. The crude product was purified by Prep-HPLC with the following conditions (2-AnalyseHPLC-SHIMADZU(HPLC-10)): Column, XB ridge Shield RP 18 OBD Column, 30* 150mm,5um; mobile phase, Wateri 1 OMMOL/L NH4HC03) and ACN (25.0% ACN up to 45.0% in 7 min); Detector, UV 254220nm. This resulted in 15.2 mg (12%) of the title compound as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromopyrazine, and friends who are interested can also refer to it.
Reference:
Patent; EPIZYME, INC.; CAMPBELL, John Emmerson; DUNCAN, Kenneth William; MILLS, James Edward John; MUNCHHOF, Michael John; (202 pag.)WO2019/79485; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem