In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 762240-92-6 as follows. Safety of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
Example-1 Preparation of (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl) butan-2-ylcarbamate of Formula (III) In 250 mL three necked round bottom flask equipped with mechanical stirrer, thermometer and an addition funnel, were added 400 mL DMF, 100 g (3R)-N-(tert-butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl) butanoic acid of Formula (V) and 72 g 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyrazine hydrochloride of Formula (IV). The reaction mixture was cooled to 0 to 5 C. and 106 g TBTU was added. 116.3 g DIPEA was added to the reaction mixture and stirred for 1 hour. After the completion of reaction, 1 L water and 600 mL 1% NaHCO3 was added. The reaction mixture was stirred for 1 hour at 25 C. to 35 C. The precipitates were filtered and washed with water. The product was dried under vacuum at 60 C. for 4 hours to obtain 151.9 g of title compound.
According to the analysis of related databases, 762240-92-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CADILA HEALTHCARE LIMITED; DWIVEDI, Shri prakash Dhar; SINGH, Kumar Kamlesh; NARODE, Sunil Dnyaneshwar; PATEL, Dhaval Jashvantbhai; SOLANKI, Kirtipalsinh Sajjansinh; US2015/87834; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem