Application of 56423-63-3,Some common heterocyclic compound, 56423-63-3, name is 2-Bromopyrazine, molecular formula is C4H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of BB-7 (79 mg, 0.24 mmol), 2-bromopyrazine (48 mg, 0.319 mmol), t-BuOK (8 mg, 0.72 mmol, as 1.0 M solution in dry THF) and iPr-PEPPSI catalyst (9mg, 0.014 mmol) in toluene (3 mL) was heated at 70C in a microwave reactor for 1 h. Then, water was added and the RM was extracted with EtOAc.The volatiles were removed under reduced pressure and the residue was purified by CC (PF-3OSIHP/4G/ Cy IEtOAc) to yield the desired compound (23 mg, 23%).LC-MS (Method 2): m/z [M+H] = 412.3 (MW calc. = 411.16); R = 0.662 mi 1H-NMR (600MHz, DMSOd 6): oe = 1.59 (s, 3H); 2.33 (m, br, 2H); 3.82 (s, 3H); 3.86 (t, J = 6.0 Hz, 2H), 4.12 (m, 2H); 6.78 (s, 1H);7.85 (d, J= 2.4 Hz, 1H), 8.10 (m, 1H), 8.37 (d, J= 2.4 Hz, 1H), 8.59 (s, 2H), 10.32 (s, 1H).
The synthetic route of 56423-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NORDHOFF Sonja; OBERBORSCH Stefan; RITTER Stefanie; VOSS Felix; WACHTEN Sebastian; WO2015/197188; A1; (2015);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem