These common heterocyclic compound, 59489-71-3, name is 2-Amino-5-bromopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 59489-71-3
Example 71 2 (R)- (3-CHLORO-METHANESULFONYL-PHENYL)-3-CYCLOPENTYL-N- [5- (3-METHOXY-PHENYL)- PYRAZIN-2-YL]-PROPIONAMIDE [000334] Nitrogen was bubbled through a solution of 3-methoxyphenyl boronic acid (393 mg, 2.59 mmol), 2-AMINO-5-BROMOPYRAZINE (300 mg, 1.72 mmol), sodium carbonate (603 mg, 5.69 mmol), dimethoxyethane (10 mL), and water (3 mL) for 15 min. After this time, the solution was treated with dichlorobis (triphenylphosphine) palladium (II) (121 mg, 0.17 mmol), and the resulting reaction mixture was heated at 90C for 2 days. The reaction was then poured into water (50 mL) and extracted with ethyl acetate (3 x 50 mL). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated in vacuo. Biotage chromatography (FLASH 40S, Silica, 40/60 hexanes/ethyl acetate) afforded 5- (3-METHOXY-PHENYL)-PYRAZIN-2-YLAMINE (218 mg, 63%) as a light yellow solid: mp 113.2-115. 5C ; EI-HRMS m/e calcd for CLLHIIN3O (M+) 201.0902, found 201.0905.
The synthetic route of 2-Amino-5-bromopyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/52869; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem