Structural and solvent effects on alkaline hydrolysis of heterocyclic esters was written by Rao, G. Venkoba;Balakrishnan, M.;Venkatasubramanian, N.;Subramanian, P. V.;Subramanian, V.. And the article was included in Indian Journal of Chemistry in 1981.Reference of 6924-68-1 This article mentions the following:
Saponification of the 3 isomeric Et pyridinecarboxylates (I–III), Et pyridine-2-acetate (IV), Et pyridine-3-acetate (V), Et pyrazinecarboxylate, Et furan-2-carboxylate, and Et thiophene-2-carboxylate, are examined in aqueous EtOH and DMSO-water media. The structural effects on the hydrolysis of I–III have been discussed in terms of aza 锜?values. The assumption of treating ring nitrogen as a ring substituent is truly valid. Structural effects vis-a-vis solvent effects on the hydrolysis of IV and V are discussed in detail. Application of Laidler-Landskroener equation to the saponification of these esters in aqueous EtOH is found to give normal values for the radius of the transition state. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Reference of 6924-68-1).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Reference of 6924-68-1