Synthesis of pyrido[2,3-b]pyrazines and study of their antitumor activity was written by Postovskii, I. Ya.;Charushin, V. N.;Mokrushina, G. A.;Kotovskaya, S. K.;Barybin, A. S.;Chupakhin, O. N.;Chernyshev, A. I.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1982.Reference of 322-46-3 This article mentions the following:
Cyclocondensation of I (R = Me2N, morpholino, piperidino) with glyoxal gave 50-60% II which were quaternized with MeI to give 60-64% III. II (R = Me2N) and III (R = Me2N) inhibited sarcoma 37 in mice 50-55% at 50-100 娓璯/kg dosage. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Reference of 322-46-3