Month: February 2023

Tris(dipivaloylmethanato)europium-induced shifts of proton resonances in π-deficient nitrogen heterocycles was written by Armarego, W. L. F.;Batterham, T. J.;Kershaw, J. R.. And the article was included in Organic Magnetic Resonance in 1971.Product Details of 322-46-3 This article mentions the following:

Tris(dipivaloylmethanato)europium, [Eu(DPM)3], induced shifts of the PMR of pyridine and its 2-Me, 3-Me, 2,3-di-Me and 2,5-di-Me derivatives, pyridazine, pyrimidine, pyrazine, quinoline, isoquinoline, 1,6-, 1,7- and 1,8-naphthyridine, cinnoline, phthalazine, quinazoline, quinoxaline, 1,4,5- and 1,4,6-triazanaphthalene, pteridine, acridine, phenanthridine and 1,10-phenanthroline, were measured for solutions containing 0.1, 0.3, and 0.5 molar equivalents of Eu(DPM)3. Differences in the behavior of these heterocycles are discussed in terms of the steric relations between the heterocycle and the complex. The 3 cos2 * dhi term, present in the expression for calculating pseudocontact shifts, is important. The order of basicity of these heterocycles, as measured by their pKa values, cannot be used to predict the order of Eu(DPM)3 induced chem. shifts. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Product Details of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Product Details of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Conjugated microporous polymers as heterogeneous photocatalysts for efficient degradation of a mustard-gas simulant was written by Zhi, Yongfeng;Yao, Zhengjie;Jiang, Wenbo;Xia, Hong;Shi, Zhan;Mu, Ying;Liu, Xiaoming. And the article was included in ACS Applied Materials & Interfaces in 2019.Name: 5,8-Dibromoquinoxaline This article mentions the following:

Compared with traditional metal-based photosensitizers, heterogeneous and organic photocatalysts with visible-light activity are more environmentally friendly and sustainable. The simultaneous introduction of electron-rich and electron-deficient units in donor-acceptor typed conjugated microporous polymer (CMP) photocatalysts can significantly enhance their visible-light harvesting and separation efficiency of photogenerated carriers. Here, two carbazole-based CMPs (CzBSe-CMP and CzBQn-CMP) were successfully constructed through a cost-effective process. They show inherent porosity with large Brunauer-Emmett-Teller surface area and excellent thermal and chem. stability. Their photoelec. properties, energy levels, optical band gaps, transient photocurrent response, and photocatalytic activity could be conveniently tailored through tuning the electron-deficient moiety in polymer networks. More importantly, CzBSe-CMP was found to be a superior solid photocatalyst for selective photo-oxidation of mustard gas simulant 2-chloroethyl Et sulfide into a nontoxic product by using mol. oxygen as a sustainable oxygen source under visible-light illumination. In addition, the obtained CMP-based photocatalysts also showed excellent recyclability and could be reutilized through adding more simulants or a simple separation procedure. The current contribution provides great application prospects for CMPs as metal-free, solid photocatalysts in organic transformation and environmental protection. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Name: 5,8-Dibromoquinoxaline).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Name: 5,8-Dibromoquinoxaline

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Improved organic hydrogen carriers with superior thermodynamic properties was written by Lu, Rui-Feng;Boethius, Gustav;Wen, Shu-Hao;Su, Yan;Deng, Wei-Qiao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.Recommanded Product: 322-46-3 This article mentions the following:

By incorporation of N atoms into naphthalene, we present a theor. investigation to seek improved organic hydrogen carriers with an explicit guideline. The release of H₂ is found to be greatly favored thermodynamically and the corresponding cycloalkanes possess high hydrogen storage capacity. This offers extensive candidates for practical applications of the promising hydrogen energy. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Recommanded Product: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Recommanded Product: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Discovery of potent colony-stimulating factor 1 receptor inhibitors by replacement of hinge-binder moieties was written by Lee, Jung Wuk;Park, Jiwon;Kim, Jina;Kim, Jihyung;Choi, Changyu;Min, Kyung Hoon. And the article was included in European Journal of Medicinal Chemistry in 2021.HPLC of Formula: 1150566-27-0 This article mentions the following:

Tumor-associated macrophages (TAMs) are predominantly associated with tumor growth. Colony-stimulating factor 1 receptor (CSF1R) acts as a key regulator of TAM survival and differentiation and is a mol. target for cancer therapies. Herein, novel CSF1R inhibitors were identified through a replacement strategy for the hinge-binding moiety. The introduction of imidazo[1,2-a]pyridine I or pyrazolo[1,5-a]pyridine II as hinge binders led to 87% and 82% inhibition at 10 nM for CSF1R in the enzymic assay, with IC₅₀ values of 25 nM and 27 nM in MNFS60 cells, resp. These derivatives significantly inhibited CSF1R phosphorylation in cells. Author approach could be utilized as a strategy to discover novel kinase inhibitors. In the experiment, the researchers used many compounds, for example, Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (cas: 1150566-27-0HPLC of Formula: 1150566-27-0).

Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (cas: 1150566-27-0) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.HPLC of Formula: 1150566-27-0

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Structural and magnetic behavior of the kinked chain Cu(hfac)₂(tan) and its relevance to Cu(NO₃)₂(tan) (hfac = hexafluoroacetylacetonate; tan = 1,4,5-triazanaphthalene) was written by Manson, Jamie L.. And the article was included in Inorganic Chemistry in 2003.Electric Literature of C7H5N3 This article mentions the following:

When stoichiometric amounts of Cu(hfac)₂·H₂O and 1,4,5-triazanaphthalene (tan) were combined in MeOH, green crystals of Cu(hfac)₂(tan) were formed. Its structure was determined at low temperature (P2₁/c; a 8.3308(4), b 14.8945(7), c 18.3046(10) Å, β 99.298(2)°) and found to consist of a novel kinked-chain arrangement where N atoms on opposite sides of the tan ligand bridge Cu(hfac)₂ moieties together. Long axial Cu-N bonds lead to rather weak (J/k_B = -0.06(5) K) antiferromagnetic interactions according to a Bonner-Fisher fit of the magnetic susceptibility data. The magnetic behavior demonstrated by Cu(hfac)₂(tan) contrasts markedly with that of Cu(NO₃)₂(tan), as reported by Hatfield and co-workers, and is attributed to the differing orientations of the Cu d_x²-y² magnetic orbital. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Electric Literature of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Electric Literature of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Surface self-assembly involving the interaction between S and N atoms was written by Wu, Tianhao;Xue, Na;Wang, Zhichao;Li, Jie;Li, Yaru;Huang, Wei;Shen, Qian;Hou, Shimin;Wang, Yongfeng. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Quality Control of 5,8-Dibromoquinoxaline This article mentions the following:

Controllable mol. self-assembly is vital for nanostructure construction. Here, three different self-assembling networks are realized by varying the chem. composition of the mol. building blocks of the same architecture. This is the first time that S···N electrostatic attraction has been employed to regulate surface self-assembly. All mol. structures are characterized using low-temperature scanning tunnelling microscopy. The d. functional theory calculations elaborate the structure formation mechanism. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Quality Control of 5,8-Dibromoquinoxaline).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Quality Control of 5,8-Dibromoquinoxaline

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis, Configurational Assignment and Conformational Analysis of β-Hydroxy Sulfoxides, Bioisosteres of Oxisuran Metabolites, and their O-Methyl Derivatives was written by Alvarez-Ibarra, C.;Cuervo-Rodriguez, R.;Fernandez-Monreal, M. C.;Ruiz, M. P.. And the article was included in Journal of Organic Chemistry in 1994.Synthetic Route of C7H8N2O2 This article mentions the following:

Synthesis, configurational assignment, and conformational anal. of diastereoisomers of 2-(methylsulfinyl)-1-(2-quinolyl)ethanol, 2-(methylsulfinyl)-1-(1-isoquinolyl)ethanol, 2-(methylsulfinyl)-1-(2-pyrazinyl)ethanol, and their O-Me derivatives are reported. The configurational assignment and conformational anal. of the two diastereoisomers of β-hydroxy sulfoxides and β-methoxy sulfoxides have been carried out from the observed vicinal coupling constants using the mol. mechanics force field (MMX) and the Altona relationship as fundamental tools. The conformational equilibrium is explained in terms of polar and steric factors. Of significant importance was the role of intramol. hydrogen bonding in the RS/SR isomers of β-hydroxy sulfoxides. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Synthetic Route of C7H8N2O2).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Synthetic Route of C7H8N2O2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Design and synthesis of indobufen esters was written by Li, Feng;Wang, Jie;Li, Jia-ming;Zuo, Jian. And the article was included in Anhui Yiyao in 2015.Computed Properties of C8H12N2O This article mentions the following:

Indobufen was used as starting material, and three Indobufen esters were designed and synthesized based on association principle and prodrug principle of medicinal chem. The structures of the target compounds were characterized by IR, MS, ¹H NMR and ¹³C NMR. The anti-platelet aggregation activity of the target compounds is being tested in vitro. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Computed Properties of C8H12N2O).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Computed Properties of C8H12N2O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The electronic spectra of N-heteroaromatic systems. IX. n → π transitions of polycyclic azines was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1962.Reference of 322-46-3 This article mentions the following:

The visible and ultraviolet spectra of some polycyclic azines were measured in hydrocarbon and hydroxylic solvents. The frequencies of the n → π bands are determined primarily by the energy of the lowest unoccupied orbital in the corresponding aromatic hydrocarbon and the 1-electron charge ds. in that orbital at the positions occupied by N atoms, together with ground-state interaction between the lone pair orbitals in the ortho diazines. The intensities of the diazine n → π bands increase with the sum of the 1-electron charge ds. at the N positions of the lowest unoccupied π orbital. Compounds investigated are quinoline, quinoxaline, 1,5- and 1,8-naphthyridine, cinnoline, quinazoline, phthalazine, 1,2,4-, 1,4,5-, and 1,4,6-triazanaphthalene, 1,3,5,8-and 1,4,5,8-tetraazanaphthalene, and phenazine. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Reference of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Molecular 5,8-π-extended quinoxaline derivatives as chromophores for photoluminescence applications was written by Aguiar, Leonardo de O.;Junior, Adalberto S. L.;Bechtold, Ivan H.;Curcio, Sergio Fernando;Cazati, Thiago;Alves, Tiago V.;Vieira, Andre Alexandre. And the article was included in Journal of Molecular Liquids in 2019.Reference of 148231-12-3 This article mentions the following:

The 5,8-π-extended quinoxaline derivatives are widely studied due to their well-known photophys. and electrochem. properties. In order to investigate the structure-property relationship, a novel series of fluorescent calamitic liquid crystals based on the quinoxaline heterocycle was successfully synthesized and characterized. The final mols. presented calamitic mesomorphism with nematic and smectic phases. These compounds displayed intense green photoluminescence under UV light excitation in solution and in the solid state. In chloroform solution, the fluorescence quantum yields (Φ_FL = 0.54-0.62) of the quinoxaline-based derivatives were significantly higher than those previously described for similar benzothiadiazoles. The maximum emission peaks were between 511 and 520 nm with singlet excited-state lifetimes in the nanosecond timescale. The solvatochromism studies showed a significant dependence of the emission on the polarity of the solvent. Doping of the quinoxalines with fullerene C₆₀ suggests a charge transfer process, this being dependent on the π-conjugate core. The energy band gaps predicted with DFT calculations are in excellent agreement with the exptl. data. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Reference of 148231-12-3).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Reference of 148231-12-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem