Synthesis and conformational study of β-hydroxy sulfones, bioisosteres of oxisuran metabolites, and their O-methyl derivatives was written by Alvarez-Ibarra, C.;Cuervo-Rodriguez, R.;Fernandez-Monreal, M. C.;Ruiz, M. P.. And the article was included in Tetrahedron in 1996.Recommanded Product: 6924-68-1 This article mentions the following:
The synthesis and conformational anal. of 2-(methylsulfonyl)-1-(2-quinolyl)ethanol, 2-(methylsulfonyl)-1-(1-isoquinolyl)ethanol, 2-(methylsulfonyl)-1-(2-pyrazinyl)ethanol, and the O-Me derivatives, 2-(methylsulfonyl)-1-(methoxy)-1-(2-quinolyl)ethane and 2-(methylsulfonyl)-1-(methoxy)-1-(1-isoquinolyl)ethane, are reported. The conformational anal. of β-hydroxy sulfones and β-methoxy sulfones has been carried out from the observed vicinal coupling constants, using a mol. mechanics force field (MMX) and the Altona relationship as fundamental tools. Polar interactions are the main factor that control the stability of the different conformations, with steric effects and intramol. hydrogen bonding less important contributions. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Recommanded Product: 6924-68-1).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Recommanded Product: 6924-68-1