Synthesis, spectral characterization, dna interaction and anticancer evaluation of transition metal complexes of hydroxamic acid derivative was written by Hegde, Divya S.;Gudasi, Kalagouda B.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2016.Safety of Ethyl pyrazine-2-carboxylate This article mentions the following:
A novel tetradentate chelating ligand, N閳?(1-(hydroxyamino)-1-oxopropan-2-ylidene)pyrazine-2-carbohydrazide and its Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized and characterized by elemental analyses, spectral (vibrational, electronic, 1H NMR,13C NMR and Mass) and thermal studies. The interaction of ligand and complexes with calf-thymus DNA (CT-DNA) has been extensively studied using absorption, emission, viscosity and thermal denaturation studies with E. coli DNA. The DNA cleavage ability of ligand and metal complexes was tested using plasmid pBR322 DNA by gel electrophoresis method. The compounds were evaluated for their in vitro antiproliferative activity against human cancer cells of different origin such as MCF-7, Mia-Pa-Ca-2 and DU-145 by using SRB(sulforhodamineB) assay. The copper and iron complex have shown better anticancer activity as compared to other compounds under study. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Safety of Ethyl pyrazine-2-carboxylate).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Safety of Ethyl pyrazine-2-carboxylate