Stabilizing biochemically important intermediates through metal coordination. 5,8-Bis(trimethylsilyl)-5,8-dihydropteridine and its deaza derivative was written by Bessenbacher, Christian;Kaim, Wolfgang. And the article was included in Journal of Organometallic Chemistry in 1989.Reference of 322-46-3 This article mentions the following:
Reductive trimethylsilylation of pteridine and its deaza derivatives 1,4,6- and 1,4,5-triazanaphthalene and quinoxaline yields the primary reduced forms of these heterocycles, which contain the 1,4-dihydro-1,4-diazine ring with 8 conjugated 锜?electrons as the only low mol. weight products. Although the organometallic substituents stabilize these biochem. important yet normally short-lived dihydro forms and so allow unambiguous characterization by NMR, the non-crystalline, colored compounds are still highly reactive. Unexpectedly, the deaza derivatives prove to be less electron-rich than the silylated dihydropteridine despite a clear increase in the electron d. in the aromatic ring. The characteristic conformational flexibility of these intermediates is responsible for this inverse annulation effect. Reductive trimethylsilylation of 1,5-naphthyridine yields the 1-trimethylsilyl-1,4-dihydro derivative as the major product. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Reference of 322-46-3