Design and synthesis of indobufen esters was written by Li, Feng;Wang, Jie;Li, Jia-ming;Zuo, Jian. And the article was included in Anhui Yiyao in 2015.Computed Properties of C8H12N2O This article mentions the following:
Indobufen was used as starting material, and three Indobufen esters were designed and synthesized based on association principle and prodrug principle of medicinal chem. The structures of the target compounds were characterized by IR, MS, 1H NMR and 13C NMR. The anti-platelet aggregation activity of the target compounds is being tested in vitro. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Computed Properties of C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Computed Properties of C8H12N2O