Degradation of Pharmaceuticals through Sequential Photon Absorption and Photoionization in Amiloride Derivatives was written by Jorner, Kjell;Rabten, Wangchuk;Slanina, Tomas;Proos Vedin, Nathalie;Sillen, Sara;Wu Ludvigsson, Jufang;Ottosson, Henrik;Norrby, Per-Ola. And the article was included in Cell Reports Physical Science in 2020.Related Products of 1458-01-1 This article mentions the following:
Herein, the photodegradation of analogs of amiloride, which are known to undergo photosubstitution in water was reported. Model compounds built on the same scaffold undergo clean photosubstitution also in alc. solvent, where a certain amount of photodehalogenation was normally expected. Available evidence points to a mechanism starting with photoexcitation followed by photoionization to give a radical cation intermediate. Subsequent substitution reaction with the protic solvent was assisted by a general base, possibly strengthened by the proximal solvated electron. Recombination with the solvated electron generates the observed product. Quantum chem. computations revealed that excited state antiaromaticity is relieved when an electron is ejected from the photoexcited mol. by the second photon. The mechanism indicated here could have wide applicability to photoinduced degradation of similar heteroaromatic compounds in the environment, as well as to a class of increasingly popular synthetic photoredox methods. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Related Products of 1458-01-1).
Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Related Products of 1458-01-1