Synthesis of tetramethylpyrazine derivatives and screening for 5-HT3 receptor antagonistic activity was written by Jiang, Xiang-Qing;Huang, Chuan-Man;Zhu, Li-Ping;Ye, De-Yong. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2005.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:
According to the principle of bioisosterism and the Evans’ pharmacophore model of 5-HT3 receptor antagonists, twelve tetramethylpyrazine derivatives were synthesized. The structures of the compounds were confirmed by MS, 1H NMR and HRMS. All the target compounds are unreported. The preliminary activity test showed that most of the compounds had fairly potent 5-HT3 receptor antagonistic activities, especially compound I. The conformational anal. showed that the active conformation of the compounds was quite fitted to the Evans model. This indicates that besides the three pharmacophoric elements, the aromatic ring and the substituents attached may affect the bioactivities of the compounds In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol