Decisive increase of regioselectivity in radical substitutions: Minisci reaction in the two-phase system was written by Heinisch, Gottfried;Loetsch, Gerhard;Vieboeck, Franz. And the article was included in Angewandte Chemie in 1985.Safety of Ethyl pyrazine-2-carboxylate This article mentions the following:
The ethoxycarbonylation of isonicotinonitrile by EtO2C• (formed from Et pyruvate, H2O2, FeSO4, and H2SO4 in H2O) gave I along with other mono- and disubstitution products. Addition of CH2Cl2 increased the yield of I appreciably. Similar results were obtained with nicotinonitrile and pyrazine. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Safety of Ethyl pyrazine-2-carboxylate).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Safety of Ethyl pyrazine-2-carboxylate