Intramolecular Diels-Alder reaction of pyrazines with an alkenyl side chain was written by Chen, Bin;Yang, Chu-Yao;Ye, De-Yong. And the article was included in Tetrahedron Letters in 1996.Electric Literature of C8H12N2O This article mentions the following:
Intramol. Diels-Alder reaction of a series of pyrazines bearing a 5-membered-ω-alkene side chain, I (X = O, SO, SO2, S), in refluxing trifluoroacetic acid led to the formation of bridged tricyclic compounds II. These cycloadducts underwent retro Diels-Alder reaction in refluxing nitrobenzene to give the original pyrazines. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Electric Literature of C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Electric Literature of C8H12N2O